Cryotherapy is a technique that uses an extremely cold liquid or instrument to freeze and destroy abnormal skin cells that require removal. The technique has been in use since the turn of the century, but modern techniques have made it widely available to dermatologists and primary care doctors. The technique is also known as cryocautery or cryosurgery.


Cryotherapy is used to destroy a variety of benign skin growths, such as warts, pre-cancerous lesions (actinic keratoses), and malignant lesions (basal cell and squamous cell cancers). It has been used at several medical centers for tumors of the prostate, liver, lung, breast, and brain as well as for cataracts, gynecological problems, and other diseases. The goal of cryotherapy is to freeze and destroy targeted skin growths while preserving the surrounding skin from injury.


In dermatology applications, there are three main techniques used in cryotherapy. In the simplest technique, usually reserved for warts and other benign skin growths, the physician dips a cotton swab or other applicator into a cup containing a "cryogen" such as liquid nitrogen and applies it directly to the skin growth to freeze it. At a temperature of –320°F (–196°C), liquid nitrogen is the coldest cryogen available. The goal is to freeze the skin growth as quickly as possible, and then let it thaw slowly to cause maximum destruction of the skin cells. A second application may be necessary depending on the size of the growth. In another approach, a device is used to direct a small spray of liquid nitrogen or other cryogen directly onto the skin growth. Freezing may last from five to 20 seconds, depending on the size of the lesion. A second freeze-thaw cycle may be required. Sometimes, the physician inserts a small needle connected to a thermometer into the lesion to make certain the lesion is cooled to a temperature low enough to guarantee maximum destruction. In a third option, liquid nitrogen or another cryogen is circulated through a probe to cool it to low temperatures. The probe is then brought into direct contact with the skin lesion to freeze it. The freeze time can take two to three times longer than with the spray technique.

When used for cancer treatment, cryotherapy is usually performed as follows: for external tumors, liquid nitrogen is applied directly to the cancer cells with a cotton swab or spraying device; for internal tumors, liquid nitrogen is circulated through an instrument called a cryoprobe that is placed in contact with the tumor. To guide the cryoprobe and to monitor the freezing of the cells, the treating physician uses ultrasound to guide his work and spare nearby healthy tissue.


No extensive preparation is required prior to cryotherapy. The area to be treated should be clean and dry, but sterile preparation is not necessary. Patients should know that they will experience some pain at the time of the freezing, but local anesthesia is usually not required. In dermatology applications, the physician may want to reduce the size of certain growths such as warts prior to the cryotherapy procedure, and may have patients apply salicylic acid preparations to the growth over several weeks. Sometimes, the physician will pare away some of the tissue using a device called a curette or a scalpel. In the case of cervical cryotherapy , the procedure is not performed during, or from two to three days before, the menstrual period.


In dermatology applications, redness, swelling, and the formation of a blister at the site of cryotherapy are all expected results of the treatment. A gauze dressing is applied, and patients should wash the site three or four times daily while fluid continues to ooze from the wound, usually for five to 14 days. A dry crust will form that falls off by itself. Wounds on the head and neck may take four to six weeks to heal, but those on the body, arms, and legs can take longer. Some patients experience pain at the site following the treatment. This can usually be eased with acetaminophen (Tylenol), though in some cases a stronger pain reliever may be required.


In dermatology applications, cryotherapy poses little risk and can be well tolerated by elderly and other patients who are not good candidates for other surgical procedures. As with other surgical procedures, there is some risk of scarring, infection, and damage to underlying skin and tissue. These risks are generally minimal in the hands of experienced physicians.

Care should be taken, however, in subjecting people with diabetes or certain circulation problems to cryotherapy for growths located on their lower legs, ankles, and feet. In these patients, healing can be poor and the risk of infection can be higher than for other patients.

Although cryotherapy is a relatively low-risk procedure, some side effects may occur as a result of the treatment. They include:

In cancer treatment, cryosurgery does have side effects, although they may be less severe than those associated with conventional surgery or radiation therapy. Cryosurgery of the liver may cause damage to the bile ducts or major blood vessels, which can lead to heavy bleeding or infection. Cryosurgery for prostate cancer may affect the urinary system. It also may cause incontinence (lack of control over urine flow) and impotence (loss of sexual function), although these side effects are often temporary. Cryosurgery for cervical tumors has not been shown to affect fertility, but this possibility is under study. More studies must be conducted to determine the long-term effects of cryosurgery as a cancer treatment approach.

Normal results

Some redness, swelling, blistering, and oozing of fluid are all common results of cryotherapy. Healing time can vary by the site treated and the cryotherapy technique used. When cryogen is applied directly to the growth, healing may occur in three weeks. Growths treated on the head and neck with the spray technique may take four to six weeks to heal, while growths treated on other areas of the body may take considerably longer. Cryotherapy boasts high success rates in permanently removing skin growths; even for malignant lesions such as squamous cell and basal cell cancers, studies have shown a cure rate of up to 98%. For certain types of growths such as some forms of warts, repeat treatments over several weeks are necessary to prevent the growth's return.


Alternatives to cryotherapy depend on the specific medical condition being treated. A general alternative is the use of conventional surgical procedures.

See also Cervical cryotherapy ; Cryotherapy for cataracts .



Dawber, R., G. Colver, A. Jackson, and F. Pringle. Cutaneous Cryosurgery: Principles and Clinical Practice, 2nd ed. Oxford: Blackwell Science Inc., 1996.

Korpan, N. N. Basics of Cryosurgery. New York: Springer Verlag, 2002.

Lynch, Peter J., and W. Mitchell Sams Jr. Principles and Practice of Dermatology, 2nd ed. New York: Churchill Livingstone, 1996.

Roenigk, Randall K., and Henry H. Roenigk Jr. Roenigk and Roenigk's Dermatologic Surgery: Principles and Practice. New York: Marcel Dekker, 1996.


Housman, T. S., and J. L. Jorizzo. "Anecdotal Reports of Three Cases Illustrating a Spectrum of Resistant Common Warts Treated with Cryotherapy Followed by Topical Imiquimod and Salicylic Acid." Journal of the American Academy of Dermatology 47 (October 2002): 1501–1505.

Otte, J. W., M. A. Merrick, C. D. Ingersoll, and M. L. Cordova. "Subcutaneous Adipose Tissue Thickness Alters Cooling Time during Cryotherapy." Archives of Physical and Medical Rehabilitation 83 (November 2002): 1501–1505.

Palner, E. A., et al. "Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter Trial of Cryotherapy for Retinopathy of Prematurity: Ophthalmological Outcomes at 10 Years." Archives of Ophthalmology 119 (2001): 1110–1118.

Uchio, Y., M. Ochi, A. Fujihara, N. Adachi, J. Iwasa, and Y. Sakai. "Cryotherapy Influences Joint Laxity and Position Sense of the Healthy Knee Joint." Archives of Physical and Medical Rehabilitation 84 (January 2003): 131–135.

Wozniacka, A., A. Omulecki, and J. D. Torzecka. "Cryotherapy in the Treatment of Angiolymphoid Hyperplasia with Eosinophilia." Medical Science Monitor 9 (January 2003): CS1–CS4.


American Academy of Dermatology. 930 N. Meacham Road, P.O. Box 4014, Schaumburg, IL 60168-4014. (847) 330-0230. Fax: (847) 330-0050. .

American Society for Dermatologic Surgery. 930 N. Meacham Road, PO Box 4014, Schaumburg, IL 60168-4014. (847) 330-9830. .


"Cryotherapy." Family Practice Notebook. .

Richard H. Camer

Monique Laberge, PhD


Cryotherapy is performed by the treating physician, who may be a gynecologist (cervical cryotherapy) or a dermatologist (wart removal) or an oncologist ( tumor removal ). The procedure is usually carried out on an outpatient basis, but may require a hospital setting depending on the condition requiring the cryotherapy.


Also read article about Cryotherapy from Wikipedia

User Contributions:

In 1995 I under went cervical cryotherapy due to being diagnosed with having dysplasia. It was done on an out patient basis. I did not feel any pain during the procedure and I had no anesthesia. However, as the cervical area started to "thaw" it felt similar to mild frost bite. It was uncomfortable. But, I took some ibuprofen and that took care of the pain. And I have not had to undergo the procedure again.
I went through crysourgery 3 days ago. Since then I have some heavy watery discharge, which does not worry me as much. The thing that worries me is a foul smell that comes immidiately with the discharge. Does this foul smell means I have an infection? :( I am truly nervous and I think my doctor is on his vacation and have no idea who to turn to :(
My son had the Cryotherapy on a large wart on palm of hand. It is swallon huge and blue purple. cracking and a little bleeding. Help me. is this normal.
I had cryosurgery done on some brown spots on my arms, and face. It has been 2 weeks, the blisters are gone, but I still have red spots from where the blisters was. I was wondering will these red spots go away after time ?
I had cryosurgery done on some brown spots on my arms, and face. It has been 2 weeks, the blisters are gone, but I still have red spots from where the blisters was. I was wondering will these red spots go away after time ?
Has anyone had this treatment for Bursitis or Hamstring injuries?? If so, did it help
Brenda Mackin
I have severe grannuloma annulare, going on 2 years, I have had light treatments, cream, and now taking injections. My Doctor can only give me 2 injections at a time, because she fears it will affect my bones. I am embarassed to go out, it is on my legs, thighs, knees, back, sides,breasts,even around my vaginal opening, and I'm still getting new places starting. In about 2 months, they will be as big as a quarter. Can my Doctor use cryotherapy? I have had this condition for approximately 20 years, but only a few places, which were injected and disappeared, but now I have so many, the Doctor can't get rid of them all, and they are getting bigger.I am 63 years old, and in fairly good health, no diabetis, although it runs in my family bad. Please help!!!
I underwent cryo for prostate cancer 4 year ago. On awakening I immediately had severe pain in right side. I could not stand straight but rather had to stay bent over the coffee table for almost two weeks as I couldn't straighten up due to the pain in my right leg between hip joint and inside upper right leg runnning to knee. Since that day I have had Dr's look at my hip joints and xrays, MRI's and other and no one can find why I can't walk normal on my right leg after the cryo. Could a tendon have been damaged or something akin to that during the surgery that has basically debilitated me? Any help any body can offer would be a God send to me as I'm only 65 and have to walk with a cain since the prostate cryo. Tests indicate the cancer is gone but the leg result was a horrible price to pay. Help anybody that has heard of this.
Seven days ago I underwent cyrotherapy from my dermatologist for skin treatments. I have had this treatment before but this time she happened to apply the liquid nitrogen in three different spots on the right side of my chest where I had undergone radiation treatment 8 years ago for breast cancer. Since the cyro procedure, I have had radiation pain in this area all over again, just like I had undergone my 30 day treatment again. It feels like I have the severe burns again on my skin and throughout the muscles in this area going clear thru to my back as the radiation had done. Has there ever been any connection between use of the liquid nitrogen and reactivating radiation in the body from past treatments? I feel as if a radiation (Geiger counter?) wand where to be waved over this are, the needle would go off the chart. Any insight would be greatly appreciated.
My friend in Tanzania has albinism and received cryotherapy on more than 50 spots at the same appointment last month. They swelled up in large blisters (up to 6 cm), and the pain was so bad that she couldn't sleep for 8 days. Most spots treated were below the knees and a nasty infection set in, she's on her third round of antibiotics. The doctor insists it's all "normal," but I've been worried about the infection and even the possibility of sepsis. Isn't it important to balance cancer prevention with the risk of infection, and be more conservative with the liquid nitrogen?
My cousin was dumb and used this on bare skin, where there was no wart or tag or anything. Now there is a brown spot. Is there anything she can do to help this go away and approximately how long will it take to look normal again?
I had cryotherapy for a large sun spot on my hand last week and as expected a large blister formed. I have kept it loosely covered but able to get air and kept it dry. It has been a week and it doesn't look like its going to start to go down to form a scab - looks like a huge dome on my hand - how long should can it stay as a big blister and is there a chance the skin will enjoy this new extended position and not turn into a scab? Should I go back to the doc, get it wet to encourage it to dry out, put antibiotic on it to keep it moist? so confused and could use some advice
Thank you
I had liquid nitrogen put on my lip the doctor put it on for 1 minute then added saline solution he did that 4 times after the procedure my lip turned black and part of it fell off now its oozing and sticky I have been given antibiotics and was told by day 2 od taking them it would be alot better its now day 3 and is getting worse is that normal what should I do its so painful I can't eat and am drinking threw a straw
I had this done 2 days ago to 3 fingers. My warts were on my cuticle, very large. The pain during the procedure was bearable but once I got in the car the pain set in and it became unbearable. It felt like I had a blow torch burning my finger, they were stinging and became numb and felt like they were throbbing. I took advil which helped a little bit but the pain was still there.
I just had 3 spots sprayed of this nitrogen and have felt nausea and wanted to know if there are any side effects?
I had cryotherapy done on my forehead going on 4 months ago. It is still very red it looks awful. I wish that I never had this done. I wonder if I could have something done so it will look better. It actually has an indent I think it was held on to long a deep burn and its not going away. 4months and still red and indented.
I had the treatment used on my forehead, later that day I received a blood blister, is this normal? Yes its sore to touch.
I came here to find out why I'm still having severe pain a week and a half after having cryosurgery for 2 genital warts but from the comments here I see that it must be a normal effect. I can barely sit. I had no warning that it would hurt for so long.
I had cryotherapy on my nose and I developed thick scar tissue beside it. Why?
gary, my experience, is they disturbed your sciatica, try someheat compreses and meloxicam 15mg for a wk or two!
Elizabeth BrinerGL
had actinic keratosis freeze yesterday do I was with soap and water
kerri warner
My 15 year old daughter has a very large wart on her knee. Yesterday she had cryotherapy liquid nitrogen treatment to freeze the wart off. She was in alot of pain following the treatment and a large blister formed within hours. Today the blister popped and its even more painful and swollen then yesterday. The skin around it the wart is extremely red and hot. The wart itself is really gross looking it looks like its covered in white mold or pus its severely sore and swollen and has fluid leaking and running down her leg. Is this normal?
William Brinker
Had eye surgery at va in October 3 weeks later they froze it twice and started chemo drops very painful for three or four weeks gave me all kinds of drops but pain persists but not quite as bad definetly not going away and affected eye tears all the time been almost four months now.
Is this normal and if not what may be problem?
I have a warm burning sensation (almost hurts) on the back of my calfs after I completed my treatment today. Any idea what this could be?
Annette melvin
I had cryosurgery on The back of my lower leg it was so infected I had to go to the Emergency room looked like a hole with ugly substance It is still raw after a month my dr did a culcure and CBC to see if I'm still infected. Help
Heather Fourie
I had cryotherapy done on my upper back of leg,just below my panty line just over a week ago.It is extremely painfull after I get up from sitting there something I can use to heal quicker.? I have been bathing in savlon water and dabbing with water and peroxide daily.
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William Brinker
Had eye surgery one and a half yrs ago to remove cancer-it healed nicely and started chemo drops for about two weeks and doctor called me and wanted to treat with liquid nitrogen which she did and it has been painful ever since-couple months ago went in and she took tissue from good eye and put in painful one-still painful-lost sight after nit.burn and still cannot see-only can see light.any suggestions?
I had cryotherapy on forehead acne frontal sinus seemed to grow slightly larger
On Friday I had cryotherapy liquid nitrogen treatment to freeze off some spots on my ankle on the outside had swelled since Saturday and is still swelled and it is Tuesday. I have had this done before on my body and never has it swelled. The blister is popped but then it fills up again. It does not hurt uless you poke it and I feel fine and no temp. Is this normal or should I call the doctor
I had liquid nitrogen used on the side of the penile shaft, where I had a pimple (it was originally diagnosed as a molluscum by a physician's assistant, which is why it was applied).

It blistered after a few days, and by day 4 or 5, the blister fell off and left a "crater" in the skin. It mostly healed up and now looks like very light/pinkish skin (I am on day 12). However, the area also feels a little hard. If I feel it with two fingers and move it around, it almost feels like there is a grain of rice beneath the new skin.

Is this normal? Is this just scar tissue? I'm really worried
Bonnie Faulkner
Where are the answers? I see the questions but see no answers!!

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